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In comparing highest with lowestquartiles of CACS and C-IMT for incident cardiovas-cular disease, CACS was associated with an adjustedHR of 2.3 [95% CI 1.20, 3.9] whereas the commonC-IMT was associated with an adjusted HR 2.3 [95%CI 1.3, 4.1] (34). When they compared thediagnostic accuracy of CAC to invasive angiography,they found that only 2% of those with CAC = 0 hadsignificant coronary stenosis defined as greater than50%. Therefore, risk assessment is basedon the tumor size and mitotic index (the number of mitoseson 50 high-power ?elds)

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